Significance of p16 positive expression in oropharyngeal cancers.

  title={Significance of p16 positive expression in oropharyngeal cancers.},
  author={Regiane Benez Bixofis and Laurindo Moacir Sassi and Cleverson Patussi and Juliana Elizabeth Jung and Sergio O. Ioshii and Juliana Lucena Schussel},
  journal={Asian Pacific journal of cancer prevention : APJCP},
  volume={15 23},
BACKGROUND The involvement of HPV in oral and oropharyngeal carcinogenesis was first proposed in 2004, based on epithelial HPV tropism and detection of HPV genotypes in oral squamous cell carcinoma samples. While 60-70% of oropharynx tumors may be HPV-positive, only 10 to 19% of tumors of the oral cavity, larynx and hypopharynx appear to have HPV infection. The aim of the study was to evaluate HPV infection associated with oropharyngeal cancer. MATERIALS AND METHODS Seventy-eight cases were… CONTINUE READING