Significance of nitroimidazole compounds and hypoxia-inducible factor-1 for imaging tumor hypoxia.

@article{KizakaKondoh2009SignificanceON,
  title={Significance of nitroimidazole compounds and hypoxia-inducible factor-1 for imaging tumor hypoxia.},
  author={Shinae Kizaka-Kondoh and Hideko Konse-Nagasawa},
  journal={Cancer science},
  year={2009},
  volume={100 8},
  pages={1366-73}
}
A tumor-specific microenvironment is characterized by hypoxia, in which oxygen tension is considerably lower than in normal tissues. The hypoxic status of various solid tumors has been attributed as an indicator of adverse prognosis due to tumor progression toward a more malignant phenotype with increased metastatic potential and resistance to treatment. Various exogenous and endogenous markers for hypoxia are currently available and studied in relation to each other, tumor architecture, and… CONTINUE READING
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