Significance of neonatal testicular sex steroids to defeminize anteroventral periventricular kisspeptin neurons and the GnRH/LH surge system in male rats.

@article{Homma2009SignificanceON,
  title={Significance of neonatal testicular sex steroids to defeminize anteroventral periventricular kisspeptin neurons and the GnRH/LH surge system in male rats.},
  author={Tamami Homma and Mototsugu Sakakibara and Shunji Yamada and Mika Nakamoto Kinoshita and Kinuyo Iwata and Junko Tomikawa and Tetsuhiro Kanazawa and Hisanori Matsui and Yoshihiro Takatsu and Tetsuya Ohtaki and Hirokazu Matsumoto and Yoshihisa Uenoyama and Kei-ichiro Maeda and Hiroko Tsukamura},
  journal={Biology of reproduction},
  year={2009},
  volume={81 6},
  pages={1216-25}
}
The brain mechanism regulating gonadotropin-releasing hormone (GnRH)/luteinizing hormone (LH) release is sexually differentiated in rodents. Kisspeptin neurons in the anteroventral periventricular nucleus (AVPV) have been suggested to be sexually dimorphic and involved in the GnRH/LH surge generation. The present study aimed to determine the significance of neonatal testicular androgen to defeminize AVPV kisspeptin expression and the GnRH/LH surge-generating system. To this end, we tested… CONTINUE READING

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