Significance of mutations in the androgen receptor gene in males with idiopathic infertility.

@article{Hiort2000SignificanceOM,
  title={Significance of mutations in the androgen receptor gene in males with idiopathic infertility.},
  author={Olaf Hiort and P. M. Holterhus and T Horter and Wolfgang Schulze and Britta Kremke and Monika Bals-Pratsch and Gernot H. G. Sinnecker and Klaus Kruse},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2000},
  volume={85 8},
  pages={2810-5}
}
Abnormal human spermatogenesis is caused by a variety of genetic and acquired conditions. Because spermatogenesis is dependent on androgens, some males may have a minimal form of androgen insensitivity that does not inhibit virilization but impairs fertility. This has lead us to investigate the possibility of abnormalities in the androgen receptor (AR) gene in a large cohort of males suffering from infertility of unknown cause. We studied 180 males with variable impairment of spermatogenesis… CONTINUE READING

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