Significance of marrow-derived nicotinamide adenine dinucleotide phosphate oxidase in experimental ischemic stroke.

@article{Tang2011SignificanceOM,
  title={Significance of marrow-derived nicotinamide adenine dinucleotide phosphate oxidase in experimental ischemic stroke.},
  author={Xian Nan Tang and Zhen Zheng and Rona G. Giffard and Midori A Yenari},
  journal={Annals of neurology},
  year={2011},
  volume={70 4},
  pages={
          606-15
        }
}
OBJECTIVE Reperfusion after stroke leads to infiltration of inflammatory cells into the ischemic brain. Nicotinamide adenine dinucleotide phosphate oxidase (NOX2) is a major enzyme system that generates superoxide in immune cells. We studied the effect of NOX2 derived from the immune cells in the brain and in blood cells in experimental stroke. METHODS To establish whether NOX2 plays a role in brain ischemia, strokes were created in mice, then mice were treated with the NOX2 inhibitor… CONTINUE READING

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