Significance of manipulating intratumor hypoxia in the effect on lung metastases in radiotherapy, with reference to its effect on the sensitivity of intratumor quiescent cells

@article{Masunaga2009SignificanceOM,
  title={Significance of manipulating intratumor hypoxia in the effect on lung metastases in radiotherapy, with reference to its effect on the sensitivity of intratumor quiescent cells},
  author={S. Masunaga and Y. Matsumoto and Ryoichi Hirayama and G. Kashino and H. Tanaka and M. Suzuki and Y. Kinashi and Y. Liu and K. Ando and K. Ono},
  journal={Clinical & Experimental Metastasis},
  year={2009},
  volume={26},
  pages={693-700}
}
  • S. Masunaga, Y. Matsumoto, +7 authors K. Ono
  • Published 2009
  • Medicine, Biology
  • Clinical & Experimental Metastasis
  • Purpose To evaluate the effect of manipulating intratumor hypoxia during radiotherapy on lung metastasis, referring to its effect on the sensitivity of quiescent tumor cells. Materials and Methods B16-BL6 melanoma tumor-bearing C57BL/6 mice were continuously given 5-bromo-2′-deoxyuridine (BrdU) to label all proliferating (P) cells. They received γ-ray irradiation following loading with the acute hypoxia-releasing agent nicotinamide or local hyperthermia at mild temperatures (MTH). Immediately… CONTINUE READING

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