Significance of local international sensitivity index systems for monitoring warfarin and liver function.

@article{Lee2014SignificanceOL,
  title={Significance of local international sensitivity index systems for monitoring warfarin and liver function.},
  author={H. J. Lee and Ji-Eun Kim and H. Lee and H. S. Lim and Hyun Kyung Kim},
  journal={American journal of clinical pathology},
  year={2014},
  volume={141 4},
  pages={
          542-50
        }
}
OBJECTIVES Use of a local calibrator has been recommended for standardization of the international normalized ratio (INR) and international sensitivity index (ISI). We investigated the performance of two commercial local calibrators for warfarin monitoring and determined the significance of liver-specific INR. METHODS ISI values were determined using the World Health Organization (WHO) method and two commercial local calibrators. Liver-specific ISI was determined using plasma samples from… Expand
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