Significance of human beta-defensins in the epithelial lining fluid of patients with chronic lower respiratory tract infections.

@article{Yanagi2007SignificanceOH,
  title={Significance of human beta-defensins in the epithelial lining fluid of patients with chronic lower respiratory tract infections.},
  author={Shigehisa Yanagi and Jun-ichi Ashitani and Keisuke Imai and Yuka Kyoraku and Arisa Sano and Naoyuki Matsumoto and Masamitsu Nakazato},
  journal={Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases},
  year={2007},
  volume={13 1},
  pages={63-9}
}
Human beta-defensins (hBDs) are the most abundant antimicrobial peptides in epithelial cells, and function in the host immune system. Respiratory epithelial cells express hBDs to inhibit bacterial proliferation during respiratory tract infections. The aim of this study was to investigate the release of hBDs into the respiratory tract and their benefit as a host defence system in chronic Pseudomonas aeruginosa infections. The levels of four hBD peptides (hBD-1-hBD-4) were measured in the… CONTINUE READING