Significance of hepatitis B viremia levels determined by a quantitative polymerase chain reaction assay in patients with hepatitis B e antigen–negative chronic hepatitis B virus infection

@article{Manesis2003SignificanceOH,
  title={Significance of hepatitis B viremia levels determined by a quantitative polymerase chain reaction assay in patients with hepatitis B e antigen–negative chronic hepatitis B virus infection},
  author={Emanuel K Manesis and G V Papatheodoridis and Vasilios Sevastianos and E Cholongitas and Christos Papaioannou and Stephanos J. Hadziyannis},
  journal={American Journal of Gastroenterology},
  year={2003},
  volume={98},
  pages={2261-2267}
}
OBJECTIVES:In hepatitis B e antigen (HBeAg)-negative chronic hepatitis B virus (HBV) infection, the clinical relevance of low viremia levels remains unclear. We evaluated the clinical significance of a single baseline serum HBV DNA measurement by a quantitative polymerase chain reaction (PCR) assay in this setting.METHODS:In total, 196 patients with HBeAg-negative chronic HBV infection (62 inactive carriers, 134 with chronic hepatitis B) were studied. ALT activity was normal at baseline in 25… CONTINUE READING

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