Significance of folate receptor alpha and thymidylate synthase protein expression in patients with non-small-cell lung cancer treated with pemetrexed.

@article{Christoph2013SignificanceOF,
  title={Significance of folate receptor alpha and thymidylate synthase protein expression in patients with non-small-cell lung cancer treated with pemetrexed.},
  author={Daniel Christian Christoph and Bernadette Reyna Asuncion and Biftu Hassan and Cindy H Tran and Julia D. Maltzman and Daniel J O'Shannessy and Murry W. Wynes and Thomas Christoph Gauler and Jeremias Wohlschlaeger and Mathias Hoiczyk and Martin Schuler and Wilfried E. E. Eberhardt and Fred R Hirsch},
  journal={Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer},
  year={2013},
  volume={8 1},
  pages={19-30}
}
INTRODUCTION Folate receptor alpha (FRA) regulates cellular uptake of folates and antifolates. Information about FRA protein expression in metastatic non-small-cell lung cancer (NSCLC) is limited. We investigated FRA as a biomarker for pemetrexed-based chemotherapy and compared it with thymidylate synthase (TS), the main target of pemetrexed. METHODS Pretreatment tumor specimens from 207 patients with advanced NSCLC were assessed for FRA and TS protein expression by immunohistochemistry using… CONTINUE READING
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