Significance of endangered and threatened plant natural products in the control of human disease

@article{Ibrahim2013SignificanceOE,
  title={Significance of endangered and threatened plant natural products in the control of human disease},
  author={Mohamed Ali Ibrahim and MinKyun Na and Joonseok Oh and Raymond F. Schinazi and Tami R. McBrayer and Tony Whitaker and Robert J. Doerksen and David J. Newman and Louis G Zachos and Mark T. Hamann},
  journal={Proceedings of the National Academy of Sciences},
  year={2013},
  volume={110},
  pages={16832 - 16837}
}
  • M. A. Ibrahim, M. Na, M. Hamann
  • Published 30 September 2013
  • Environmental Science
  • Proceedings of the National Academy of Sciences
Significance In this report we describe a group of highly complex glycosides active against hepatitis C virus and a separate group of natural products active against established targets for the control of diabetes mellitus. These complex metabolites were found in the rare plant Diplostephium rhododendroides Hieron. from the mountains of Ecuador. This report illustrates the human health significance of protecting rare and endangered plants for the control of new and emerging diseases. The… 
View on NAS
pnas.org
53 Citations
Background Citations
11

Figures from this paper

53 Citations

Citation Type

Citation Type

Tropospheric O 3 , the nightmare of wild plants: a review study
Ambient ozone (O3) poses a growing threat to the global ecosystems due to its high phytotoxicity: it may possibly reduce the productivity of wild plants as well as the species’ biodiversity. Asia…
Secondary metabolites from endangered Gentiana, Gentianella, Centaurium, and Swertia species (Gentianaceae): promising natural biotherapeutics
Diterpenoids from the shed trunk barks of the endangered plant Pinus dabeshanensis and their PTP1B inhibitory effects
Rare and endangered plants have proven to be better sources for drug discovery than other botanic sources. Pinus dabeshanensis is an endangered plant listed in the China Plant Red Data Book, and has…
Medicinal Plants Recommended by the World Health Organization: DNA Barcode Identification Associated with Chemical Analyses Guarantees Their Quality
TLDR
It is concluded that DNA barcoding should be used in a complementary manner for species identification with chemical analyses to detect and quantify the required chemical compounds, thus improving the quality of this class of medicines.
Threatened lycophytes and ferns in four Protected Areas of Mindanao, Philippines
There are nearly a thousand threatened species of vascular plants in the Philippines and of which about 12% are lycophytes and ferns. However, there are not enough data on the distribution of the…
The use of an integrated molecular-, chemical- and biological-based approach for promoting the better use and conservation of medicinal species: a case study of Brazilian quinas.
An analysis of the sponge Acanthostrongylophora igens' microbiome yields an actinomycete that produces the natural product manzamine A
TLDR
The first successful characterization and utilization of the microbiome of a marine invertebrate to identify a sustainable production source for an important natural product scaffold is reported, suggesting that a general strategy of analysis of the macroorganism's microbiome could significantly transform the field of natural products drug discovery.
Phytochemical and biological studies on rare and endangered plants endemic to China. Part XXII. Structurally diverse diterpenoids from the leaves and twigs of the endangered conifer Torreya jackii and their bioactivities
New Drugs from Natural Products around the World
In recent years, many new drugs have reached the market to treat a wide array of diseases and conditions that plague human existence, but there is still a vast need for new drug discovery. A major…
Lignans from the shed trunk barks of the critically endangered plant Abies beshanzuensis and their anti-neuroinflammatory activities
TLDR
Among the isolated lignans, (−)-matairesinol and (−)-arctigenin showed significant anti-neuroinflammatory activities by inhibiting the overproduction of nitric oxide in lipopolysaccharide-stimulated murine BV-2 microglial cells, with IC50 values of 11.5 and 19.0 μM, respectively.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 48 REFERENCES
Bioprospecting for Microbial Endophytes and Their Natural Products
TLDR
Endophytic microorganisms reside in the living tissues of the host plant and do so in a variety of relationships, ranging from symbiotic to slightly pathogenic, which may produce a plethora of substances of potential use to modern medicine, agriculture, and industry.
Clustered patterns of species origins of nature-derived drugs and clues for future bioprospecting
TLDR
Four lines of evidence from historical drug data, 13,548 marine natural products, 767 medicinal plants, and 19,721 bioactive natural products suggest that drugs are derived mostly from preexisting drug-productive families.
Contrasting plant diversification histories within the Andean biodiversity hotspot
TLDR
The data suggest that the disjunct small valley pockets of inter-Andean SDTF have persisted over millions of years, which are rich in endemic species but massively impacted, and merit better representation in future plans for science and conservation in Andean countries.
Ethnomedical field study in northern Peruvian Andes with particular reference to divination practices.
  • V. De Feo
  • Environmental Science
    Journal of ethnopharmacology
  • 2003
Plant extinctions and introductions lead to phylogenetic and taxonomic homogenization of the European flora
TLDR
Analysis of the large-scale effects of plant extinctions and introductions on taxonomic and phylogenetic diversity of floras across Europe reveals that plant invasions since AD 1500 exceeded extinctions, resulting in increased taxonomic diversity but decreased phylogenetically diversity within European regions.
Feedback with soil biota contributes to plant rarity and invasiveness in communities
TLDR
The results indicate that plants have different abilities to influence their abundance by changing the structure of their soil communities, and that this is an important regulator of plant community structure.
Human-caused environmental change: Impacts on plant diversity and evolution
  • D. Tilman, Clarence Lehman
  • Environmental Science
    Proceedings of the National Academy of Sciences of the United States of America
  • 2001
TLDR
In the long-term, the “weedy” taxa that became the dominants of the novel conditions imposed by global change should become the progenitors of a series of new species that are progressively less weedy and better adapted to the new conditions.
Influence of Exotic Earthworms on the Soil Organic Horizon and the Rare Fern Botrychium mormo
TLDR
The idea that exotic earthworms alter the forest floor, leading to negative changes in native vegetation is supported, which implies that this soil layer supplies a critical resource.
Extinction risks of Amazonian plant species
  • K. Feeley, M. Silman
  • Environmental Science
    Proceedings of the National Academy of Sciences
  • 2009
TLDR
It is predicted that by 2050, human land-use practices will have reduced the habitat available to Amazonian plant species by ≈12–24%, resulting in 5–9% of species becoming “committed to extinction,” significantly fewer than other recent estimates.
Climate change threats to plant diversity in Europe.
TLDR
Risks of extinction for European plants may be large, even in moderate scenarios of climate change and despite inter-model variability, according to application of International Union for Conservation of Nature and Natural Resources Red List criteria.
...
1
2
3
4
5
...