Significance of chymase-dependent matrix metalloproteinase-9 activation on indomethacin-induced small intestinal damages in rats.

@article{Kakimoto2010SignificanceOC,
  title={Significance of chymase-dependent matrix metalloproteinase-9 activation on indomethacin-induced small intestinal damages in rats.},
  author={Kazuki Kakimoto and Shinji Takai and Mitsuyuki Murano and Kumi Ishida and Yukiko Yoda and Takuya K Inoue and Denan Jin and Eiji Umegaki and Kazuhide Higuchi},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2010},
  volume={332 2},
  pages={684-9}
}
The side effects of nonsteroidal anti-inflammatory drugs (NSAIDs) include gastrointestinal damage not only in the stomach but also in the small intestine. Chymase converts promatrix metalloproteinase-9 to matrix metalloproteinase (MMP)-9, which plays an important role in NSAID-induced gastric damage, but it has been unclear whether chymase-dependent MMP-9 activation is involved in the NSAID-induced small intestinal damage. To clarify the involvement of chymase-dependent MMP-9 activation on… CONTINUE READING