Significance of cellular pharmacokinetics for the cytotoxic effects of daunorubicin.

  title={Significance of cellular pharmacokinetics for the cytotoxic effects of daunorubicin.},
  author={B{\"o}rje Andersson and Miloslav E Beran and Curt Peterson and Bernhard Tribukait},
  journal={Cancer research},
  volume={42 1},
The effect of free and DNA-linked daunorubicin on the colony-forming ability of granulocyte-macrophage committed stem cells and spleen colony-forming cells (i.e., multipotent stem cells) from normal mice has been studied in vitro and in vivo. After incubation of bone marrow cells in short-term suspension cultures, both committed and multipotent stem cells were more sensitive to the free drug than to the DNA complex, whereas the reverse was found in vivo after i.v. injection. However, when the… CONTINUE READING


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