Significance of catechol-O-methyltransferase gene polymorphism in fibromyalgia syndrome

@article{Grsoy2002SignificanceOC,
  title={Significance of catechol-O-methyltransferase gene polymorphism in fibromyalgia syndrome},
  author={Savaş G{\"u}rsoy and Emin M. Erdal and Hasan Herken and Ercan Madenci and Belgin Alaşehirli and Nurten Erdal},
  journal={Rheumatology International},
  year={2002},
  volume={23},
  pages={104-107}
}
Fibromyalgia syndrome (FS) is associated with a neuroendocrinal disorder characterized by abnormal function of the hypothalamic-pituitary-adrenal (HPA) axis, including hyperactive adrenocorticotropic hormone (ACTH) release and adrenal hyporesponsiveness. Catechol-O-methyltransferase (COMT) enzyme inactivates catecholamines and catecholamine-containing drugs. Polymorphism in the gene encodes for the COMT enzyme. For this study, the significance of COMT polymorphism was assessed in FS. There were… CONTINUE READING