Significance of aromatase activity in human breast cancer.

  title={Significance of aromatase activity in human breast cancer.},
  author={William R. Miller and Richard Anthony Hawkins and A. P. M. Forrest},
  journal={Cancer research},
  volume={42 8 Suppl},
The significance of in vitro aromatization of [7 alpha-3H]testosterone to estradiol by human breast cancer has been investigated by correlation with (a) estrogen receptor activity and (b) clinical response to endocrine therapy. Evidence for estradiol synthesis was obtained in 66 and estrogen receptor activity in 81 of 110 tumors. Whereas most estrogen receptor-positive tumors synthesized estradiol, the majority of the receptor-negative tumors did not. This tendency for aromatization to be… CONTINUE READING