Significance of angiotensin I-converting enzyme and angiotensin II type 1 receptor gene polymorphisms as risk factors for coronary heart disease.

@article{Nakauchi1996SignificanceOA,
  title={Significance of angiotensin I-converting enzyme and angiotensin II type 1 receptor gene polymorphisms as risk factors for coronary heart disease.},
  author={Yoshifumi Nakauchi and Tadashi Suehiro and Masahiro Yamamoto and Noritake Yasuoka and Kazumasa Arii and Yoshitaka Kumon and Naohisa Hamashige and Kozo Hashimoto},
  journal={Atherosclerosis},
  year={1996},
  volume={125 2},
  pages={161-9}
}
The D allele of an insertion/deletion (I/D) polymorphism in the angiotensin I-converting enzyme (ACE) gene is associated with a risk of myocardial infarction, and the relative risk associated with the ACE D allele is increased by the C allele of an angiotensin II type 1 receptor (AT1R) gene polymorphism (an A-->C transversion at nucleotide position 1166) [28]. The relation of the ACE and AT1R gene polymorphisms to coronary heart disease and the severity of coronary artery stenosis has now been… CONTINUE READING

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