Significance of aberrant glial cell phenotypes in pathophysiology of amyotrophic lateral sclerosis.

@article{Tras2017SignificanceOA,
  title={Significance of aberrant glial cell phenotypes in pathophysiology of amyotrophic lateral sclerosis.},
  author={Emiliano Tr{\'i}as and Sof{\'i}a Ibarburu and Romina Barreto-N{\'u}{\~n}ez and Luis H. Barbeito},
  journal={Neuroscience letters},
  year={2017},
  volume={636},
  pages={
          27-31
        }
}
Amyotrophic Lateral Sclerosis (ALS) is a paradigmatic neurodegenerative disease, characterized by progressive paralysis of skeletal muscles associated with motor neuron degeneration. It is well-established that glial cells play a key role in ALS pathogenesis. In transgenic rodent models for familial ALS reactive astrocytes, microglia and oligodendrocyte precursors accumulate in the degenerating spinal cord and appear to contribute to primary motor neuron death through a non-cell autonomous… CONTINUE READING
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