Significance of Z-value Statistics of Smith-Waterman Scores for Protein Alignments

  title={Significance of Z-value Statistics of Smith-Waterman Scores for Protein Alignments},
  author={Jean-Paul Comet and Jean-Christophe Aude and Eric Gl{\'e}met and Jean-Loup Risler and Alain H{\'e}naut and Piotr P. Slonimski and Jean-Jacques Codani},
  journal={Computers & chemistry},
  volume={23 3-4},
The Z-value is an attempt to estimate the statistical significance of a Smith-Waterman dynamic alignment score (SW-score) through the use of a Monte-Carlo process. It partly reduces the bias induced by the composition and length of the sequences. This paper is not a theoretical study on the distribution of SW-scores and Z-values. Rather, it presents a statistical analysis of Z-values on large datasets of protein sequences, leading to a law of probability that the experimental Z-values follow… CONTINUE READING


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