Significance of Secreted Protein Acidic and Rich in Cysteine Expression in Colorectal Carcinoma


sion of vascular endothelial growth factor (VEGF) and microvessel density in colon cancer tissues [3]. In ovarian cancer, the absence of SPARC upregulated the expressions of VEGF, VEGFR2, MMP-2, and MMP-9, thereby promoting the angiogenic and metastatic potential of these cancers [4]. SPARC is also able to inhibit VEGF-induced integrin activation and down… (More)
DOI: 10.3393/ac.2013.29.3.87


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