Significance of Plk1 regulation by miR-100 in human nasopharyngeal cancer.

  title={Significance of Plk1 regulation by miR-100 in human nasopharyngeal cancer.},
  author={Wei Shi and Nehad M Alajez and Carlo Bastianutto and Angela Bik-Yu Hui and Joseph D. Mocanu and Emma Ito and Pierre Busson and K. D. Lo and Raymond W P Ng and John Waldron and Brian O'Sullivan and Fei-fei Liu},
  journal={International journal of cancer},
  volume={126 9},
Polo-like kinase 1 (Plk1) is a critical regulator of many stages of mitosis; increasing evidence indicates that Plk1 overexpression correlates with poor clinical outcome, yet its mechanism of regulation remains unknown. Hence, a detailed evaluation was undertaken of Plk1 expression in human nasopharyngeal cancer (NPC), the cellular effects of targeting Plk1 using siRNA in combination with ionizing radiation (RT) and potential upstream microRNAs (miRs) that might regulate Plk1 expression. Using… CONTINUE READING
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