Significance of Plk1 regulation by miR-100 in human nasopharyngeal cancer.

@article{Shi2010SignificanceOP,
  title={Significance of Plk1 regulation by miR-100 in human nasopharyngeal cancer.},
  author={Wei Shi and Nehad M Alajez and Carlo Bastianutto and Angela Bik-Yu Hui and Joseph D. Mocanu and Emma Ito and Pierre Busson and K. D. Lo and Raymond W P Ng and John Waldron and Brian O'Sullivan and Fei-fei Liu},
  journal={International journal of cancer},
  year={2010},
  volume={126 9},
  pages={2036-48}
}
Polo-like kinase 1 (Plk1) is a critical regulator of many stages of mitosis; increasing evidence indicates that Plk1 overexpression correlates with poor clinical outcome, yet its mechanism of regulation remains unknown. Hence, a detailed evaluation was undertaken of Plk1 expression in human nasopharyngeal cancer (NPC), the cellular effects of targeting Plk1 using siRNA in combination with ionizing radiation (RT) and potential upstream microRNAs (miRs) that might regulate Plk1 expression. Using… CONTINUE READING
74 Citations
51 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 74 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 51 references

2588–92

  • Liu XB Wong BY Ng RW Yuen AP Wei WI. Mature miR-184 as Wong TS, 14
  • C an ce r C el l B io lo gy 2048 Plk1…
  • 2010
1 Excerpt

Molecular C an ce r C el l B io lo gy

  • W Shi, I Pataki, +6 authors FF. Liu
  • Shi et al. 2047 Int. J. Cancer:
  • 2010

Similar Papers

Loading similar papers…