Significance of Plk1 regulation by miR‐100 in human nasopharyngeal cancer

  title={Significance of Plk1 regulation by miR‐100 in human nasopharyngeal cancer},
  author={W. Shi and N. Alajez and C. Bastianutto and A. Y. Hui and J. Mocanu and Emma Ito and P. Busson and K. Lo and Raymond Ng and J. Waldron and B. O’sullivan and F. Liu},
  journal={International Journal of Cancer},
  • W. Shi, N. Alajez, +9 authors F. Liu
  • Published 2010
  • Biology, Medicine
  • International Journal of Cancer
  • Polo‐like kinase 1 (Plk1) is a critical regulator of many stages of mitosis; increasing evidence indicates that Plk1 overexpression correlates with poor clinical outcome, yet its mechanism of regulation remains unknown. Hence, a detailed evaluation was undertaken of Plk1 expression in human nasopharyngeal cancer (NPC), the cellular effects of targeting Plk1 using siRNA in combination with ionizing radiation (RT) and potential upstream microRNAs (miRs) that might regulate Plk1 expression. Using… CONTINUE READING
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