Significance of Nitric Oxide Level in Giardiasis.

  title={Significance of Nitric Oxide Level in Giardiasis.},
  author={M. Zarebavani and D. Dargahi and N. Einollahi and N. Dashti and F. Safari and M. Rezaeian},
  journal={Clinical laboratory},
  volume={63 1},
BACKGROUND Giardiasis is one of the most prevalent intestinal protozoa infections in humans. Nowadays, nitric oxide (NO) is known to be involved in the immune system against Giardia intestinalis. Therefore, the aim of the present study was to evaluate the level of NO in individuals with giardiasis in comparison to normal subjects. METHODS This descriptive study was conducted among 49 Giadia positive and 39 age and gender matched healthy volunteers. Examination of stool samples was done by wet… Expand
3 Citations
Immune response markers in sera of children infected with Giardia duodenalis AI and AII subassemblages.
No significant differences in the antibody reactivity profile or the cytokine and NOx production in the sera of children infected with AI or AII G. duodenalis variants were observed, suggesting that subtypes of the parasite do not influence the immune response profile. Expand
Plasma citrulline, arginine, nitric oxide, and blood ammonia levels in neonatal calves with acute diarrhea
Compared plasma CIT, ARG, NO, and whole blood ammonia concentrations in neonatal calves with acute diarrhea with those in healthy calves and to assess their possible relationships with diarrhea‐related criteria, changes in these variables might have diagnostic, prognostic, and therapeutic value in diarrheic newborn calves. Expand


The effects of nitric oxide on the immune response during giardiasis.
  • W. Pavanelli, F. R. Gutierrez, +5 authors M. Watanabe
  • Medicine, Biology
  • The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
  • 2010
The balance between giardial arginine consumption and epithelial NO production could contribute to the variability of the duration and severity of infections by this ubiquitous parasite. Expand
Inducible nitric oxide synthase in duodenum of children with Giardia lamblia infection.
The different morphological and immunohistochemical results in the duodenal biopsies of children with giardiasis can elucidate a variety of clinical symptoms from asymptomatic to severe infection. Expand
Trichomonas vaginalis and Giardia intestinalis Produce Nitric Oxide and Display NO‐Synthase Activity
Results add to the evidence that both T. vaginalis and G. intestinalis have evolved from organisms containing fully-functional mitochondria, and that both Giardia and trichomonads in evolutionary phylogeny has been debated mostly due to their lack of mitochondria. Expand
Assessment of the levels of nitric oxide (NO) and cytokines (IL-5, IL-6, IL-13, TNF, IFN-gamma) in giardiosis.
A lack of acute inflammatory state in the course of G. intestinalis infection was showed and even the antiparasitic treatment applied did not reduce the levels of these parameters and only caused a rise in IL-6. Expand
Arginine Consumption by the Intestinal Parasite Giardia intestinalis Reduces Proliferation of Intestinal Epithelial Cells
It is shown that arginine-withdrawal by intestinal pathogens leads to a halt in the cell cycle in IECs through reduced polyamine levels and upregulated cell cycle inhibitory genes, which is of importance with regards to intestinal tissue homeostasis that is affected through reduced cell proliferation. Expand
Molecular identification of Giardia lamblia; is there any correlation between diarrhea and genotyping in Iranian population?
It is found that genotype A is six times higher prevalence than genotype B in patients with diarrhea in this study, which suggests that using sensitive techniques and larger sample for detection of G. lamblia genotypes and their subtypes would be necessary for investigation the immune system respond and correlation with diarrhoea in the future studies in Iran. Expand
Immune response to Giardia duodenalis.
  • G. Faubert
  • Biology, Medicine
  • Clinical microbiology reviews
  • 2000
The identification of antigens that play a role in acquired immunity has been difficult because of the occurrence of antigenic variation and because, Giardia being an ubiquitous organism, it is possible that the antigenic profiles of isolates from different geographic areas will vary. Expand
Immunological aspects of Giardia infections
It is suggested that T lymphocytes and interleukin-6 (IL-6) contribute to clearance of Giardia infection via mechanisms independent of antibodies, and Nitric oxide (NO) appears to contribute to host clearance of Giulia trophozoites. Expand
Mucosal defences against Giardia
  • L. Eckmann
  • Biology, Medicine
  • Parasite immunology
  • 2003
Mucosal defences against Giardia must act in the small intestinal lumen in the absence of induction by classical inflammatory mediators, and elucidation of the key anti‐giardial effector mechanisms will be important for selecting the best adjuvants in the rational development of vaccination strategies. Expand
Role of nitric oxide and superoxide in Giardia lamblia killing.
  • P. Fernandes, J. Assreuy
  • Biology, Medicine
  • Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
  • 1997
The results indicate that NO accounts for Giardia trophozoites killing and this effect is not mediated by peroxynitrite. Expand