Significance of MDM2 and P14 ARF polymorphisms in susceptibility to differentiated thyroid carcinoma.

Abstract

BACKGROUND Murine double minute 2 (MDM2) oncoprotein and p14(ARF) tumor suppressor play pivotal roles in regulating p53 and function in the MAPK pathway, which is mutated frequently in differentiated thyroid carcinoma (DTC). We hypothesized that functional polymorphisms in the promoters of MDM2 and p14(ARF) contribute to the interindividual difference in… (More)
DOI: 10.1016/j.surg.2012.11.009

Cite this paper

@article{Zhang2013SignificanceOM, title={Significance of MDM2 and P14 ARF polymorphisms in susceptibility to differentiated thyroid carcinoma.}, author={Fenghua Zhang and Li Xu and Qingyi Wei and Xi-Cheng Song and Erich M Sturgis and Guojun Li}, journal={Surgery}, year={2013}, volume={153 5}, pages={711-7} }