Significance of MAD2 expression to mitotic checkpoint control in ovarian cancer cells.

@article{Wang2002SignificanceOM,
  title={Significance of MAD2 expression to mitotic checkpoint control in ovarian cancer cells.},
  author={Xianghong Wang and Dong-Yan Jin and Raymond Wai-Man Ng and Huichen Feng and Yong Chuan Wong and Annie L M Cheung and Sai Wah Tsao},
  journal={Cancer research},
  year={2002},
  volume={62 6},
  pages={
          1662-8
        }
}
Chromosome instability is a commonly observed feature in ovarian carcinoma. Mitotic checkpoint controls are thought to be essential for accurate chromosomal segregation, and MAD2 is a key component of this checkpoint. In this study, we investigated the competence of the mitotic checkpoint and its relationship to the expression of MAD2 protein in seven ovarian cancer cell lines. We found that a significant number (43%, three of seven cell lines) of the tested ovarian cancer cells failed to… CONTINUE READING

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Significance of MAD2 expression to mitotic checkpoint control in ovarian cancer cells

  • X Wang, D-Y Jin, RW Ng, H Feng, YC Wong, ALM Cheung
  • Cancer Res
  • 2002
1 Excerpt

Spindle checkpoint protein bub 1 is required for kinetochore localization of mad 1 , mad 2 , bub 3 , and cenp - e , independently of its kinase activity

  • E. Pennisi
  • J . Cell Biol .
  • 2001

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