Significance of Lyt phenotypes: Lyt2 antibodies block activities of T cells that recognize class 1 major histocompatibility complex antigens regardless of their function.

@article{Swain1981SignificanceOL,
  title={Significance of Lyt phenotypes: Lyt2 antibodies block activities of T cells that recognize class 1 major histocompatibility complex antigens regardless of their function.},
  author={Susan L Swain},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1981},
  volume={78 11},
  pages={7101-5}
}
  • Susan L Swain
  • Published 1981 in
    Proceedings of the National Academy of Sciences…
The effect of anti-Lyt2 on the generation of helper T-cell function and on cytotoxic effects specific for subregions of the major histocompatibility complex (MHC) was determined. The addition of anti-Lyt2 without complement to in vitro cultures blocked the generation of allogeneic MHC-induced help and lymphokine production and cytotoxic effects when the response was directed against allogeneic class 1 MHC antigens (K and D gene products of the mouse H-2 complex) but had no effect when these… CONTINUE READING

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