Significance of IL-1beta and IL-1 receptor antagonist (IL-1Ra) in bronchoalveolar lavage fluid (BALF) in patients with diffuse panbronchiolitis (DPB).

@article{Kadota1996SignificanceOI,
  title={Significance of IL-1beta and IL-1 receptor antagonist (IL-1Ra) in bronchoalveolar lavage fluid (BALF) in patients with diffuse panbronchiolitis (DPB).},
  author={Jun-ichi Kadota and Yoshito Matsubara and Yuji Ishimatsu and Miwa Ashida and Koh Abe and Ryo Shirai and Koji Iida and Kazuyoshi Kawakami and Hajime Taniguchi and Takuma Fujii and Mitsuko Kaseda and S Kawamoto and Shigeru Kohno},
  journal={Clinical and experimental immunology},
  year={1996},
  volume={103 3},
  pages={461-6}
}
We evaluated the effect of erythromycin therapy on pulmonary function tests and the airway inflammatory response of patients with DPB. The number of neutrophils in BALF obtained from DPB patients was significantly higher than that of healthy volunteers. Treatment with erythromycin (600 mg/day for 12.9+/-9.5 months (mean +/- s.d.)) significantly reduced the total number of cells and neutrophils in the airway, and significantly improved pulmonary function tests. The levels of IL-1beta and IL-8… CONTINUE READING
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