Significance of IGFBP-4 in the development of fetal growth restriction.


BACKGROUND Fetal growth restriction (FGR) is a leading cause of perinatal mortality and morbidity. Animal studies suggest dysregulation of IGF-binding protein (IGFBP)-4 is significant in the development of FGR, although human data are lacking. We postulated that IGFBP-4 is expressed at the maternal fetal interface and plays a role in regulating IGF… (More)
DOI: 10.1210/jc.2011-2511


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