Significance of CTLA-4 and CD14 genetic polymorphisms in clinical outcome after allogeneic stem cell transplantation

  title={Significance of CTLA-4 and CD14 genetic polymorphisms in clinical outcome after allogeneic stem cell transplantation},
  author={Alessandro Maria Vannucchi and Stefano Guidi and Paola Guglielmelli and Stephie Glinz and Letizia Lombardini and Alessandro Busca and Franco Locatelli and Anna Maria Dall'omo and Alberto Bosi},
  journal={Bone Marrow Transplantation},
In addition to the genes involved in the ‘HLA barrier’ in solid organ and hematopoietic stem cell transplantation (HSCT), and to the polymorphisms of the KIR family genes of natural killer cell receptors, there has been growing attention in the past few years regarding the role of other gene polymorphisms of molecules potentially involved in immune reactions following HSCT. In particular, attention has been paid to the sequence polymorphisms of cytokine and cytokine gene receptor genes, as… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 11 extracted citations

Genetic variation in donor CTLA-4 regulatory region is a strong predictor of outcome after allogeneic hematopoietic cell transplantation for hematologic malignancies.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation • 2012
View 2 Excerpts


Publications referenced by this paper.
Showing 1-9 of 9 references

Genetic regulation of rejection and survival following human lung transplantation by the innate immune receptor CD14.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons • 2007

Costimulation blockade and its possible future use in clinical transplantation.

Transplant international : official journal of the European Society for Organ Transplantation • 2006

Similar Papers

Loading similar papers…