Significance of AKT in gastric cancer (Review).

  title={Significance of AKT in gastric cancer (Review).},
  author={Takamitsu Sasaki and Hiroki Kuniyasu},
  journal={International journal of oncology},
  volume={45 6},
AKT is a serine/threonine kinase activated downstream of integrin, which is a receptor for various pro-proliferation and bioactive substances as well as the extracellular matrix receptor. The activation of AKT often contributes to tumorigenesis and plays a role in regulating cell motility, which is critical for local invasion and metastasis. In recent years, it has also drawn attention as a target of new molecular-targeted agents. When analyzing the role of AKT in cancer cells, it is important… CONTINUE READING
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