Significance and strategies in developing delivery systems for bio-macromolecular drugs

@article{He2013SignificanceAS,
  title={Significance and strategies in developing delivery systems for bio-macromolecular drugs},
  author={Huining He and Qiuling Liang and Meong Cheol Shin and Kyuri Lee and Junbo Gong and Junxiao Ye and Quan Liu and Jingkang Wang and Victor C. Yang},
  journal={Frontiers of Chemical Science and Engineering},
  year={2013},
  volume={7},
  pages={496-507}
}
Successful development of a new drug is prohibitively expensive, and is estimated to cost approximately $100—500 million US dollars for a single clinical drug. Yet, a newly developed drug can only enjoy its patent protection for 18 years, meaning that after this protected time period, any company can manufacture this product and thus the profit generated by this drug entity would reduce dramatically. Most critically, once a drug is being synthesized, its physical, chemical, and biological… Expand

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References

SHOWING 1-10 OF 77 REFERENCES
Drug-polymer conjugates: potential for improved chemotherapy.
TLDR
The basic principles for design of soluble polymeric drug delivery systems are explained and illustrated using examples drawn from studies on the development of N-(2-hydroxypropyl)methacrylamide copolymer conjugates for use in cancer chemotherapy. Expand
ATTEMPTS system: a macromolecular prodrug strategy for cancer drug delivery.
TLDR
The ATTEMPTS approach provides a multi-functionalized system incorporating the features of targeting, prodrug-like, triggerable release, and cell penetration ability for the delivery of macromolecular anticancer agents. Expand
Drug Delivery Systems: Entering the Mainstream
TLDR
There is considerable interest in exploiting the advantages of DDS for in vivo delivery of new drugs derived from proteomics or genomics research and for their use in ligand-targeted therapeutics. Expand
HPMA copolymer-anticancer drug conjugates: design, activity, and mechanism of action.
  • J. Kopeček, P. Kopec̆ková, T. Minko, Z. Lu
  • Medicine
  • European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
  • 2000
TLDR
The data obtained indicated that macromolecular therapeutics activated different signaling pathways and possessed a different mechanism of action than free drugs, which bodes well for the success of future research aimed at identification of new intracellular molecular targets. Expand
Antibody directed enzyme prodrug therapy (ADEPT): a review of the experimental and clinical considerations.
TLDR
It is concluded that ADEPT holds the potential of an effective and relatively non-toxic treatment of cancer and it is expected that the research which is in progress will makeADEPT an important element of the anticancer armament. Expand
Antibody directed enzymes revive anti-cancer prodrugs concept.
TLDR
Within a few years of the beginnings of cancer chemotherapy anticancer prodrugs were being synthesised, one of the compounds produced at the Chester Beatty had a profound effect on growth of the Walker rat carcinoma, both in vivo and in culture, whilst it had little or no effect on other cancers. Expand
Designer genes: recombinant antibody fragments for biological imaging.
  • A. Wu, P. Yazaki
  • Biology, Medicine
  • The quarterly journal of nuclear medicine : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology
  • 2000
TLDR
Ease of engineering and expression, combined with novel specificities that will arise from advances in genomic and combinatorial approaches to target discovery, will usher in a new era of recombinant antibodies for biological imaging. Expand
Tumor vascular permeability, accumulation, and penetration of macromolecular drug carriers.
TLDR
Increasing the molecular weight of dextran statistically significantly reduced its tumor vascular permeability and had the highest accumulation in solid tumors but were largely concentrated near the vascular surface. Expand
ATTEMPTS: a heparin/protamine-based delivery system for enzyme drugs.
TLDR
The results suggest that heparin/protamine-based enzyme delivery systems may be a useful tool to improve current enzyme therapeutic status, as well as thrombolytic therapy, by both regulating the release of active enzyme and aborting the associated systemic toxic effect. Expand
Nanoparticles in cancer therapy and diagnosis.
TLDR
The in vivo fate of these systems, after intravascular or tumoral administration, is discussed, as well as the mechanism involved in tumor regression, and the application of nanoparticles in imaging for cancer diagnosis is focused on. Expand
...
1
2
3
4
5
...