Significance analysis of time course microarray experiments.

@article{Storey2005SignificanceAO,
  title={Significance analysis of time course microarray experiments.},
  author={John D. Storey and Wenzhong Xiao and Jeffrey T. Leek and Ronald G. Tompkins and Ronald W. Davis},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 36},
  pages={12837-42}
}
Characterizing the genome-wide dynamic regulation of gene expression is important and will be of much interest in the future. However, there is currently no established method for identifying differentially expressed genes in a time course study. Here we propose a significance method for analyzing time course microarray studies that can be applied to the typical types of comparisons and sampling schemes. This method is applied to two studies on humans. In one study, genes are identified that… CONTINUE READING
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