Signet ring cells in esophageal and gastroesophageal junction carcinomas have a more aggressive biological behavior.

@article{Nafteux2014SignetRC,
  title={Signet ring cells in esophageal and gastroesophageal junction carcinomas have a more aggressive biological behavior.},
  author={Philippe Robert Nafteux and Toni E M R Lerut and Patrick James Villeneuve and Jeroen M Dhaenens and Gert de Hertogh and J. Moons and Willy J Coosemans and Hans Van Veer and Paul R De Leyn},
  journal={Annals of surgery},
  year={2014},
  volume={260 6},
  pages={1023-9}
}
OBJECTIVE To clarify the biologic behavior of esophageal signet ring cell (SRC) carcinomas of the esophagus and gastroesophageal junction (GEJ). To evaluate the accuracy of pretreatment biopsies in diagnosing true SRC carcinoma. BACKGROUND In contrast with gastric cancer, little is known about the biologic behavior and prognosis of SRC. METHODS All adenocarcinomas (ADC) of the esophagus and GEJ-patients undergoing primary resection between 1990 and 2009 were included (n = 920). Specimens… CONTINUE READING

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