Signatures of protein-DNA recognition in free DNA binding sites.

@article{Locasale2009SignaturesOP,
  title={Signatures of protein-DNA recognition in free DNA binding sites.},
  author={Jason W. Locasale and Andrew A Napoli and Shengfeng Chen and Helen M. Berman and Catherine L. Lawson},
  journal={Journal of molecular biology},
  year={2009},
  volume={386 4},
  pages={1054-65}
}
One obstacle to achieving complete understanding of the principles underlying sequence-dependent recognition of DNA is the paucity of structural data for DNA recognition sequences in their free (unbound) state. Here, we carried out crystallization screening of 50 DNA duplexes containing cognate protein binding sites and obtained new crystal structures of free DNA binding sites for three distinct modes of DNA recognition: anti-parallel beta strands (MetR), helix-turn-helix motif + hinge helices… CONTINUE READING

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