Signatures of inflammation and impending multiple organ dysfunction in the hyperacute phase of trauma: A prospective cohort study

@article{Cabrera2017SignaturesOI,
  title={Signatures of inflammation and impending multiple organ dysfunction in the hyperacute phase of trauma: A prospective cohort study},
  author={C. Cabrera and J. Manson and Joanna M Shepherd and H. Torrance and D. Watson and M. P. Longhi and M. Hoti and Minal B. Patel and M. O’Dwyer and S. Nourshargh and D. Pennington and Michael Barnes and K. Brohi},
  journal={PLoS Medicine},
  year={2017},
  volume={14}
}
Background Severe trauma induces a widespread response of the immune system. This “genomic storm” can lead to poor outcomes, including Multiple Organ Dysfunction Syndrome (MODS). MODS carries a high mortality and morbidity rate and adversely affects long-term health outcomes. Contemporary management of MODS is entirely supportive, and no specific therapeutics have been shown to be effective in reducing incidence or severity. The pathogenesis of MODS remains unclear, and several models are… Expand
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