Signatures of environmental exposures using peripheral leukocyte gene expression: tobacco smoke.

@article{Lampe2004SignaturesOE,
  title={Signatures of environmental exposures using peripheral leukocyte gene expression: tobacco smoke.},
  author={Johanna W. Lampe and Sergey B. Stepaniants and Mao Mao and Jerald P Radich and Hongyue Dai and Peter S. Linsley and Stephen H. Friend and John D. Potter},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  year={2004},
  volume={13 3},
  pages={445-53}
}
Functional biological markers of environmental exposures are important in epidemiological studies of disease risk. Such markers not only provide a measure of the exposure, they also reflect the degree of physiological and biochemical response to the exposure. In an observational study, using DNA microarrays, we show that it is possible to distinguish between 85 individuals exposed and unexposed to tobacco smoke on the basis of mRNA expression in peripheral leukocytes. Furthermore, we show that… CONTINUE READING

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