Signatures of T Cells as Correlates of Immunity to Francisella tularensis

@inproceedings{Enesltt2012SignaturesOT,
  title={Signatures of T Cells as Correlates of Immunity to Francisella tularensis},
  author={Kjell Enesl{\"a}tt and Monica Normark and Rafael Bj{\"o}rk and Cecilia Rietz and Carl Zingmark and Lawrence A. Wolfraim and Svenja St{\"o}ven and Anders Sj{\"o}stedt},
  booktitle={PloS one},
  year={2012}
}
Tularemia or vaccination with the live vaccine strain (LVS) of Francisella tularensis confers long-lived cell-mediated immunity. We hypothesized that this immunity depends on polyfunctional memory T cells, i.e., CD4(+) and/or CD8(+) T cells with the capability to simultaneously express several functional markers. Multiparametric flow cytometry, measurement of secreted cytokines, and analysis of lymphocyte proliferation were used to characterize in vitro recall responses of peripheral blood… CONTINUE READING