Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1

  title={Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1},
  author={Benilde Jim{\'e}nez and Olga V. Volpert and Susan E Crawford and Maria Febbraio and Roy L Silverstein and No{\"e}l P. Bouck},
  journal={Nature Medicine},
Thrombospondin-1 (TSP-1) is a naturally occurring inhibitor of angiogenesis that limits vessel density in normal tissues and curtails tumor growth. Here, we show that the inhibition of angiogenesis in vitro and in vivo and the induction of apoptosis by thrombospondin-1 all required the sequential activation of CD36, p59fyn, caspase-3 like proteases and p38 mitogen-activated protein kinases. We also detected increased endothelial cell apoptosis in situ at the margins of tumors in mice treated… CONTINUE READING
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