Signals from the Fourth Dimension Regulate Drug Relapse

  title={Signals from the Fourth Dimension Regulate Drug Relapse},
  author={Patrick J. Mulholland and L Judson Chandler and Peter W. Kalivas},
  journal={Trends in Neurosciences},
Despite the enormous societal burden of alcohol and drug addiction and abundant research describing drug-induced maladaptive synaptic plasticity, there are few effective strategies for treating substance use disorders. Recent awareness that synaptic plasticity involves astroglia and the extracellular matrix is revealing new possibilities for understanding and treating addiction. We first review constitutive corticostriatal adaptations that are elicited by and shared between all abused drugs… CONTINUE READING

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