Signals from embryonic fibroblasts induce adult intestinal epithelial cells to form nestin-positive cells with proliferation and multilineage differentiation capacity in vitro.

@article{Wiese2006SignalsFE,
  title={Signals from embryonic fibroblasts induce adult intestinal epithelial cells to form nestin-positive cells with proliferation and multilineage differentiation capacity in vitro.},
  author={Cornelia Wiese and Alexandra Rolletschek and Gabriela Kania and Anne Navarrete-Santos and Sergey V. Anisimov and Barbara Steinfarz and Kirill V Tarasov and Sheryl A Brugh and Ihor Zahanich and Christiane R{\"u}schenschmidt and Heinz Beck and Przemyslaw Blyszczuk and Jaroslaw Czyz and J{\"u}rgen F. Heubach and Ursula Ravens and Olaf Horstmann and Luc St-Onge and Thomas Braun and Oliver Bruestle and Kenneth R. Boheler and Anna M. Wobus},
  journal={Stem cells},
  year={2006},
  volume={24 9},
  pages={2085-97}
}
The intestinal epithelium has one of the greatest regenerative capacities in the body; however, neither stem nor progenitor cells have been successfully cultivated from the intestine. In this study, we applied an "artificial niche" of mouse embryonic fibroblasts to derive multipotent cells from the intestinal epithelium. Cocultivation of adult mouse and human intestinal epithelium with fibroblast feeder cells led to the generation of a novel type of nestin-positive cells (intestinal epithelium… CONTINUE READING
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