Signalling through the lipid products of phosphoinositide-3-OH kinase

@article{Toker1997SignallingTT,
  title={Signalling through the lipid products of phosphoinositide-3-OH kinase},
  author={A. C. Toker and Lewis C. Cantley},
  journal={Nature},
  year={1997},
  volume={387},
  pages={673-676}
}
When a stimulatory agonist molecule binds at the exterior of the cell membrane, a second messenger transduces the signal to the interior of the cell. Second messengers can be derived from phospholipids in the membrane by the action of the enzymes phospholipase C or phosphoinositide-3-OH kinase (PI(3)K). PI(3)K is a key player in many cellular responses, including the movement of organelle membranes, shape alteration through rearrangement of cytoskeletal actin, transformation and chemotaxis. But… CONTINUE READING
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