Signalling through the leukotriene B4 receptor involves both alphai and alpha16, but not alphaq or alpha11 G-protein subunits.

@article{Gaudreau1998SignallingTT,
  title={Signalling through the leukotriene B4 receptor involves both alphai and alpha16, but not alphaq or alpha11 G-protein subunits.},
  author={R{\'e}mi Gaudreau and Christian Le Gouill and S M{\'e}taoui and S. Lemire and Jana Stankova and Marek Rola-Pleszczynski},
  journal={The Biochemical journal},
  year={1998},
  volume={335 ( Pt 1)},
  pages={
          15-8
        }
}
COS-7 cells transfected with the leukotriene (LT) B4 receptor (BLTR) cDNA were unable to produce LTB4-induced inositol phosphates (IPs) in spite of the presence of endogenous Galphai, Galphaq and Galpha11 proteins. Co-transfection of BLTR with Galpha16, however, resulted in high levels of IP production, which were 17-, 10- and 6-fold higher than with co-transfected Galpha11, Galphaq and Galpha14, respectively. Co-transfection of BLTR with phospholipase C (PLC) beta2, on the other hand, resulted… CONTINUE READING

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Exploring the pharmacology of the leukotriene B4 receptor BLT1, without the confounding effects of BLT2.

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International Union of Pharmacology XXXVII. Nomenclature for leukotriene and lipoxin receptors.

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