Signalling through the MHC class II cytoplasmic domain is required for antigen presentation and induces B7 expression

@article{Nabavi1992SignallingTT,
  title={Signalling through the MHC class II cytoplasmic domain is required for antigen presentation and induces B7 expression},
  author={Nasrin Nabavi and Gordon J Freeman and Agn{\`e}s Gault and D. Godfrey and Lee M. Nadler and L. H. Glimcher},
  journal={Nature},
  year={1992},
  volume={360},
  pages={266-268}
}
CLASS II major histocompatibility complex (MHC) molecules function as antigen-presenting elements as well as signal transducers on B lymphocytes. We previously reported that a B lym-phoma cell transfectant, 5C2, expressing genetically engineered I-Ak molecules with truncated cytoplasmic domains was severely impaired in both antigen presentation and in anti-Ia-induced intracytoplasmic signalling1–5. These two functions could be restored by preculturing 5C2 cells with cyclic AMP analogues6,7… CONTINUE READING
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