Signalling through the JAK–STAT pathway in the developing brain

@article{Cattaneo1999SignallingTT,
  title={Signalling through the JAK–STAT pathway in the developing brain},
  author={Elena Cattaneo and Luciano Conti and CLAUDIO DE-FRAJA},
  journal={Trends in Neurosciences},
  year={1999},
  volume={22},
  pages={365-369}
}
The JAK -STAT (Janus kinase-signal transducer and activator of transcription) signalling pathway that is stimulated by cytokines has been much investigated in haematopoietic cells, but recent data indicate that this pathway is also present and active during neuronal and glial differentiation. Furthermore, it is now clear that growth factors other than the classical cytokines can act through this pathway and that physiological inhibitors of this signalling cascade exist. Thus, the JAKs, the… CONTINUE READING

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