Signalling specificity of Ser/Thr protein kinases through docking-site-mediated interactions.

@article{Biondi2003SignallingSO,
  title={Signalling specificity of Ser/Thr protein kinases through docking-site-mediated interactions.},
  author={Ricardo M Biondi and Angel R Nebreda},
  journal={The Biochemical journal},
  year={2003},
  volume={372 Pt 1},
  pages={1-13}
}
Signal transduction pathways use protein kinases for the modification of protein function by phosphorylation. A major question in the field is how protein kinases achieve the specificity required to regulate multiple cellular functions. Here we review recent studies that illuminate the mechanisms used by three families of Ser/Thr protein kinases to achieve substrate specificity. These kinases rely on direct docking interactions with substrates, using sites distinct from the phospho-acceptor… CONTINUE READING

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