Signalling properties of FLT4, a proteolytically processed receptor tyrosine kinase related to two VEGF receptors.

@article{Pajusola1994SignallingPO,
  title={Signalling properties of FLT4, a proteolytically processed receptor tyrosine kinase related to two VEGF receptors.},
  author={Katri Pajusola and Olga N Aprelikova and Giuliana Pelicci and Herbert A. Weich and Lena Claesson-Welsh and Kari Alitalo},
  journal={Oncogene},
  year={1994},
  volume={9 12},
  pages={3545-55}
}
The FLT4, FLT1 and KDR/FLK1 genes encode structurally similar endothelial cell receptor tyrosine kinases. Recently it has been shown that the FLT1 and KDR/FLK-1 proteins function as high-affinity receptors for vascular endothelial growth factor (VEGF). Here we show that FLT4 does not act as a receptor for VEGF, as VEGF did not show specific binding to the FLT4 tyrosine kinase or induce its autophosphorylation. Also, FLT4 did not interact with KDR in response to VEGF. However, when fused with… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 48 extracted citations

Similar Papers

Loading similar papers…