Signalling pathways that mediate skeletal muscle hypertrophy and atrophy

  title={Signalling pathways that mediate skeletal muscle hypertrophy and atrophy},
  author={D. Glass},
  journal={Nature Cell Biology},
  • D. Glass
  • Published 2003
  • Medicine, Biology
  • Nature Cell Biology
  • Atrophy of skeletal muscle is a serious consequence of numerous diseases, including cancer and AIDS. Successful treatments for skeletal muscle atrophy could either block protein degradation pathways activated during atrophy or stimulate protein synthesis pathways induced during skeletal muscle hypertrophy. This perspective will focus on the signalling pathways that control skeletal muscle atrophy and hypertrophy, including the recently identified ubiquitin ligases muscle RING finger 1 (MuRF1… CONTINUE READING
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