Signalling pathways that mediate skeletal muscle hypertrophy and atrophy

@article{Glass2003SignallingPT,
  title={Signalling pathways that mediate skeletal muscle hypertrophy and atrophy},
  author={D. Glass},
  journal={Nature Cell Biology},
  year={2003},
  volume={5},
  pages={87-90}
}
  • D. Glass
  • Published 2003
  • Medicine, Biology
  • Nature Cell Biology
  • Atrophy of skeletal muscle is a serious consequence of numerous diseases, including cancer and AIDS. Successful treatments for skeletal muscle atrophy could either block protein degradation pathways activated during atrophy or stimulate protein synthesis pathways induced during skeletal muscle hypertrophy. This perspective will focus on the signalling pathways that control skeletal muscle atrophy and hypertrophy, including the recently identified ubiquitin ligases muscle RING finger 1 (MuRF1… CONTINUE READING
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    References

    SHOWING 1-10 OF 61 REFERENCES
    Identification of Ubiquitin Ligases Required for Skeletal Muscle Atrophy
    • 2,763
    A protein kinase B-dependent and rapamycin-sensitive pathway controls skeletal muscle growth but not fiber type specification
    • 368
    • PDF
    Calcineurin Is Required for Skeletal Muscle Hypertrophy*
    • 277
    • PDF
    Localized Igf-1 transgene expression sustains hypertrophy and regeneration in senescent skeletal muscle
    • 1,045
    • Highly Influential
    • PDF
    Stimulation of Slow Skeletal Muscle Fiber Gene Expression by Calcineurin in Vivo *
    • 433
    • PDF