Signalling pathways from NADPH oxidase-4 to idiopathic pulmonary fibrosis.

  title={Signalling pathways from NADPH oxidase-4 to idiopathic pulmonary fibrosis.},
  author={Bruno Crestani and Val{\'e}rie Besnard and Jorge Boczkowski},
  journal={The international journal of biochemistry & cell biology},
  volume={43 8},
This review focuses on the roles of NADPH oxidase/NOX proteins in idiopathic pulmonary fibrosis (IPF) pathophysiology and in the signalling pathways involved in IPF. NOX proteins are membrane-associated multi-unit enzymes that catalyze the reduction of oxygen using NADPH as an electron donor. Recent studies indicate that NOX4 is induced in pulmonary fibroblasts in response to TGF-β. TGF-β or PDGF induce myofibroblast proliferation, differentiation, migration, contractility and extracellular… CONTINUE READING

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