Signalling or binding: the role of the platelet-activating factor receptor in invasive pneumococcal disease.

@article{Iovino2013SignallingOB,
  title={Signalling or binding: the role of the platelet-activating factor receptor in invasive pneumococcal disease.},
  author={Federico Iovino and Matthijs C. Brouwer and Diederik van de Beek and Grietje Molema and Jetta J. E. Bijlsma},
  journal={Cellular microbiology},
  year={2013},
  volume={15 6},
  pages={
          870-81
        }
}
Streptococcus pneumoniae (the pneumococcus) is an opportunistic human pathogen, which causes serious invasive disease such as pneumonia, bacteraemia and meningitis. The interaction of the bacteria with host receptors precedes the development of invasive disease. One host receptor implicated in pneumococcal adhesion to, invasion of and ultimately translocation of cell layers is the platelet-activating factor receptor (PAFR). PAFR is a G-protein coupled receptor which binds PAF, a potent… CONTINUE READING
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