Signalling of the Ret receptor tyrosine kinase through the c-Jun NH2-terminal protein kinases (JNKs): evidence for a divergence of the ERKs and JNKs pathways induced by Ret

@article{Chiariello1998SignallingOT,
  title={Signalling of the Ret receptor tyrosine kinase through the c-Jun NH2-terminal protein kinases (JNKs): evidence for a divergence of the ERKs and JNKs pathways induced by Ret},
  author={Mario Chiariello and Roberta Visconti and Francesca Carlomagno and Rosa Marina Melillo and Cecilia Bucci and Vittorio de Franciscis and Gary M. Fox and Shuqian Jing and Omar Adrian Coso and J. Silvio Gutkind and Alfredo Fusco and Massimo Santoro},
  journal={Oncogene},
  year={1998},
  volume={16},
  pages={2435-2445}
}
The RET proto-oncogene encodes a functional receptor tyrosine kinase (Ret) for the Glial cell line Derived Neurotrophic Factor (GDNF). RET is involved in several neoplastic and non-neoplastic human diseases. Oncogenic activation of RET is detected in human papillary thyroid tumours and in multiple endocrine neoplasia type 2 syndromes. Inactivating mutations of RET have been associated to the congenital megacolon, i.e. Hirschprung's disease. In order to identify pathways that are relevant for… CONTINUE READING

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