Signalling mechanisms underlying subversion of the immune response by the filarial nematode secreted product ES-62.

Abstract

Secretion of immunomodulatory molecules is a key strategy employed by pathogens to enable their survival in host organisms. For example, arthropod-transmitted filarial nematodes, which achieve longevity within the infected host by suppressing and modulating the host immune response, produce excretory-secretory (ES) products that have been demonstrated to… (More)

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